Breaking Free From Depression

Depression is often mistaken for ordinary sadness, but clinically it is something profoundly different: a medical illness that can alter the way the brain processes emotion, motivation, and even hope itself.

In this episode of Road to Resilience, host Stephen Calabria speaks with James Murrough, MD, PhD, to discuss how groundbreaking neuroimaging research explains why depression may leave the brain "entrapped" in inefficient patterns of activity, 

The conversation explores the difference between sadness and clinical depression, why chronic stress can reshape the brain, how behavioral therapy and medication help people break free from depression's grip, and why the brain's extraordinary capacity for change offers genuine reason for hope.

Visit https://www.mountsinai.org/clinical-trials to see if you're eligible to enroll in a clinical trial with the Mount Sinai Health System.

Check out more episodes of Road to Resilience —as well as guest pictures, transcripts, and more— on the Mount Sinai website.

Road to Resilience brings you stories and insights to help you thrive in a challenging world. From fighting burnout and trauma to building resilient families, we explore what’s possible when science meets the human spirit.

Transcript

SPEAKER_01 0:05

Hey New Yorkers, it's your dog mayor Simon. If there's one thing about this city I find crappy, it's people who don't pick up after their dogs. It's the number one rule about number two. Always bring your poop bags on your walks. Nobody wants to always bring your poop bags on your walks and always bring and always scoop that poop. Nobody wants your dirty business to suddenly be their dirty business. So remember, New Yorkers, bring those bags and scoop that poop. It's your sworn duty.

SPEAKER_00 0:52

Paid for by politics international. Paid for by politics international. Paid for by paid for by Politics International. Paid for by Politics International. Paid for by Politics International. Paid for by Politics International.

SPEAKER_01 1:36

Hey New Yorkers, it's your dog mayor Simon. New York is facing a crisis in our overcrowded shelters, with places like New York City animal control often at full capacity. That's why it's important to spay and neuter your pets. It prevents unplanned litters and eases overcrowding. Believe me, it must be really bad if I'm promoting spaying and neutering. If I'm promoting spaying and neutering. Believe me, it must be really bad if I'm promoting spaying and neutering. So remember, New Yorkers, get your dogs and cats spayed or neuters. Get your dogs and cats spayed or neuters. Spayed or neutered. Now let's not end on that. Let's please change the subject. Something, anything. Hey what's up, New Yorkers? It's your dog Mayor Simon. Like many dogs, I may be smart, but sometimes I get lost. And if your pet gets lost, sometimes a collar ain't enough. And that's not the knock dog collars. I know some New Yorkers find them quite useful. But microchips are even better. They make sure your pet is traceable and that anything ever happens, and that if anything ever happens, there's a better chance your fur baby will come home safe and sound. So remember, folks, be safe with your dog collar and get your pets microchipped. So remember, folks, get your pets microchipped and be safe with your dog collars. Hey there, New Yorkers, it's your dog Mayor Simon. There's so many pets in need of a loving home right now that are up for adoption. True story. I myself was adopted from Texas. Can't you tell by the accent? That's why you should adopt, not shop, when looking for your next furry friend. When looking for your next furry family member. There are puppy mills out there that don't have your animals. There are puppy mills out there that there are puppy mills out there that don't have animals' best interests at heart or yours. Adopting and not shopping, adopting and not shopping helps free up space in overcrowded shelters and gives pups like me a second chance. So remember, New Yorkers, adopt, don't shop. It's what your mayo would do.